Torpid mouse

Torpid mouse


2001年から主に小児科医・麻酔科医として働いてきました。2004年にKatharin Dausmann氏によってマダガスカルに生息するキツネザルが冬眠することが発見されました(Dausmann KH, Nature, 2004)。この衝撃的な報告を目にした瞬間から、自然界で自然に行われていることを医療に応用することに興味を持ち始めました。 神戸理化学研究所の生命システム研究センター 合成生物学グループ で遺伝子改変動物へ対して睡眠の定量的評価を行うことで哺乳類の睡眠制御機構について研究を行いました。2015年から神戸理化学研究所の網膜再生医療研究開発プロジェクトにて哺乳類の能動的低代謝のメカニズムについて研究をはじめました。最終目標は臨床応用するために人間を安全に冬眠させることです。


I have been working as a clinician (pediatrician and anesthetist) since 2001. The amazing discovery of hibernating tropical primates, which was done by Kathrin Dausmann on 2004 (Dausmann KH, Nature, 2004), inspired me to take a step in the field of biomedical applications of natural phenomena like hibernation. I studied the mechanism of homeostatic regulation of mammalian sleep using quantitative sleep evaluation for genetically modified animals at Laboratory for Synthetic Biology, RIKEN, Kobe. From 2015, I moved to Laboratory for Retinal Regeneration, RIKEN and I am focusing on understanding of active hypometabolsim in mammals. The final goal is to develop a safe method to make human hibernate for clinical applications.

Journal Publications

  1. Sunagawa, G.A.*, Takahashi M, 2016. (* corresponding author)
    Hypometabolism during Daily Torpor in Mice is Dominated by Reduction in the Sensitivity of the Thermoregulatory System
    Sci Rep., doi:10.1038/srep37011
  2. Iraha, S., Hirami, Y., Ota S., Sunagawa, G.A., Mandai, M., Tanihara, H., Takahashi, M., Kurimoto, Y., 2016.
    Efficacy of valproic acid for retinitis pigmentosa patients: a pilot study.
    Clinical Ophthalmology, Volume 10, 1375–1384. doi:10.2147/OPTH.S109995
  3. Fujii, M.*, Sunagawa, G.A.*, Kondo, M., Takahashi, M., Mandai, M., 2016. (* co-first author)
    Evaluation of micro Electroretinograms Recorded with Multiple Electrode Array to Assess Focal Retinal Function.
    Sci Rep., 6, 30719. doi:10.1038/srep30719
  4. Tatsuki, F.*, Sunagawa, G.A.*, Shi, S.*, Susaki, E.A.*, Yukinaga, H., Perrin, D., Sumiyama, K., Ukai-Tadenuma, M., Fujishima, H., Ohno, R., Tone, D., Ode, K.L., Matsumoto, K., Ueda, H.R., 2016. (* co-first author)
    Involvement of Ca2+-Dependent Hyperpolarization in Sleep Duration in Mammals.
    Neuron 1–16. doi:10.1016/j.neuron.2016.02.032
  5. Sunagawa, G.A.*, Sumiyama, K.*, Ukai-Tadenuma, M., Perrin, D., Fujishima, H., Ukai, H., Nishimura, O., Shi, S., Ohno, R., Narumi, R., Shimizu, Y., Tone, D., Ode, K.L., Kuraku, S., Ueda, H.R., 2016. (* co-first author)
    Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene.
    Cell Rep. 14, 662–677. doi:10.1016/j.celrep.2015.12.052
  6. Sunagawa, G.A., Séi, H., Shimba, S., Urade, Y., Ueda, H.R., 2013.
    FASTER: an unsupervised fully automated sleep staging method for mice.
    Genes Cells 18, 1–17. doi:10.1111/gtc.12053
  7. Pagliaro, P., Paolocci, N., Isoda, T., Saavedra, W.F., Sunagawa, G., Kass, D.A., 2000.
    Reversal of glibenclamide-induced coronary vasoconstriction by enhanced perfusion pulsatility: possible role for nitric oxide.
    Cardiovasc Res. 45, 1001–9. doi:10.1016/S0008-6363(99)00414-9
  8. Kawada, T., Sunagawa, G., Takaki, H., Shishido, T., Miyano, H., Miyashita, H., Sato, T., Sugimachi, M., Sunagawa, K., 1999.
    Development of a servo-controller of heart rate using a treadmill.
    Circ. J. 63, 945–50. doi:10.1253/jcj.63.945
  9. Pagliaro, P., Senzaki, H., Paolocci, N., Isoda, T., Sunagawa, G., Recchia, F.A., Kass, D.A., 1999.
    Specificity of synergistic coronary flow enhancement by adenosine and pulsatile perfusion in the dog.
    Physiol. 520, 271–280. doi:10.1111/j.1469-7793.1999.00271.x